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Polyoxypregnane Glycosides from Root of Marsdenia tenacissima and Inhibited Nitric Oxide Levels in LPS Stimulated RAW 264.7 Cells
| First Author: |
Na, Z |
| Abstract: |
Six new polyoxypregnane glycosides, marstenacisside F1-F3 (1-3), G1-G2 (4-5) and H1 (6), as well as 3-O-beta-D-glucopyranosyl-(1 -> 4)-6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandropyranosyl-11 alpha,12 beta-di-O-benzoyl-tenacigenin B (7), were isolated from the roots of Marsdenia tenacissima. Their structures were established by an extensive interpretation of their 1D and 2D NMR and HRESIMS data. Compounds 1-7 were tenacigenin B derivatives with an oligosaccharide chain at C-3. This was the first time that compound 7 had been isolated from the title plant and its H-1 and C-13 NMR data were reported. Compounds 4 and 5 were the first examples of C-21 steroid glycoside bearing unique beta-glucopyranosyl-(1 -> 4)-beta-glucopyranose sugar moiety. All the isolated compounds were evaluated for anti-inflammatory activity by inhibiting nitric oxide (NO) production in the lipopolysaccharide-induced RAW 264.7 cells. The results showed that marstenacisside F1 and F2 exhibited significant NO inhibitory activity with an inhibition rate of 48.19 +/- 4.14% and 70.33 +/- 5.39%, respectively, at 40 mu M, approximately equal to the positive control (L-NMMA, 68.03 +/- 0.72%). |
| Contact the author: |
Na, Z |
| Page Number: |
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| Issue: |
2 |
| Subject: |
Biochemistry & Molecular Biology; Chemistry, Multidisciplinary |
| Impact Factor: |
4.6 |
| Authors units: |
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| PubYear: |
2023 |
| Volume: |
28 |
| Publication Name: |
MOLECULES |
| The full text link: |
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| ISSN: |
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